くすりのしおり

Internal
Revised: 5/2018

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Votrient Tablets 200mg
 Active ingredient:
Pazopanib hydrochloride
 Dosage form:
light red tablet, major axis: 14.3 mm, minor axis: 5.6 mm, thickness: 5.3 mm
 Print on wrapping:
ヴォトリエント 200 mg, Votrient 200mg, GS JT

Effects of this medicine

This medicine shows anti-tumor effects by inhibiting cancer cell proliferation and receptors associated with vascularization.
It is usually used to treat malignant soft-tissue tumor, or radically unresectable or metastatic renal cell carcinoma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 4 tablets (800 mg as pazopanib) at a time, once a day at least 1 hour before meals or 2 hours after meals. The dosage may be adjusted according to the patient's condition. However, the maximum daily dose is 4 tablets (800 mg). Strictly follow the instructions.
  • If you miss a dose, take the missed dose on an empty stomach as soon as possible on the same day. However, wait at least 12 hours before taking the next dose. If you notice it the next day, continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Use a sure contraceptive method to prevent pregnancy during and certain time period after taking this medicine, since this medicine may affect the fetus.
  • While you are on this medicine, avoid taking grapefruit and grapefruit juice since they may affect the effects of this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, hypertension, fatigue, nausea, hair discoloration, decreased appetite, hepatic dysfunction, taste abnormality, vomiting, palmar-plantar erythrodysesthesia syndrome (redness, swelling, chapped skin and pain in the hands and feet), and decreased body weight. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • general malaise, nausea, yellow discoloration of the skin or white of eyes [hepatic failure, hepatic dysfunction]
  • headache, dizziness, palpitation [hypertension, hypertensive crisis]
  • breathing difficulty, palpitation, chest pain [cardiac dysfunction, ventricular arrhythmia]
  • fever, dry cough, breathing difficulty [interstitial pneumonitis]
  • slow healing of the wound [delayed wound healing]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacy or medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

Keywords Search

 

 

 

 

Advanced Search

Browse by drug name A-Z
Browse by drug name A-Z