くすりのしおり

Internal
Published: 6/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
LENVIMA Capsules 10mg
 Active ingredient:
Lenvatinib mesilate
 Dosage form:
yellowish red to yellow capsule, full length: 14.3 mm, No.4 capsule
 Print on wrapping:
(face) レンビマ10mg, (back) Lenvima, ∈ LENV10mg, レンビマ

Effects of this medicine

This medicine exerts anti-tumor effects by inhibiting tumor proliferation and vascularization through inhibition of kinases associated with tumor progression.
It is usually used to treat radically unresectable thyroid cancer.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 24 mg of the active ingredient at a time, once a day. The dosage may be adjusted according to your symptoms. This preparation contains 10 mg of the active ingredient in a capsule. Strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should not take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Measure your blood pressure periodically.
  • This medicine may cause fatigue, asthenia or dizziness. Pay close attention when performing dangerous operations such as driving a car.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hypertension, diarrhea, loss of appetite, weight loss, nausea, fatigue, stomatitis, and hand-foot syndrome (pain, redness and swelling, sloughed skin, or blisters in palms/soles). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • significant elevation of blood pressure, semi-consciousness, severe headache [hypertension]
  • anemic symptoms such as lightheadedness and dizziness, vomiting of blood, black stool [hemorrhage]
  • disturbance of consciousness, headache or chest pain, breathing difficulty [arterial thromboembolism, venous thromboembolism]
  • palpitation, breathing difficulty, disturbed pulse [cardiac disorder]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Keep in press-through package (PTP) sheet just before taking.
  • Discard the remainder. Do not store them. Ask the pharmacist and the medical institution how to discard them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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