くすりのしおり

Internal
Revised: 10/2014

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
IMATINIB Tablets 200mg "MEIJI"
 Active ingredient:
Imatinib mesilate
 Dosage form:
dusky yellowish red to deep yellowish red tablet with a split line, diameter: 10.1 mm, thickness: 6.0 mm
 Print on wrapping:
イマチニブ200mg「明治」, MS061, IMATINIB200mg「MEIJI」

Effects of this medicine

This medicine inhibits abnormal activities of tyrosine kinase (Bcr-Abl) involved in the growth of cells to suppress cancer cell proliferation.
It is usually used to treat chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphatic leukemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For adults with chronic myelogenous leukemia: In general, take 2 tablets (400 mg of imatinib) at a time in chronic phase or 3 tablets (600 mg) at a time in accelerated phase or blastic phase, once a day, after meal. The dosage may be adjusted according to the results of blood tests, age and symptoms, and may be increased up to 3 tablets (600 mg) at a time once a day in chronic phase or up to 2 tablets (400 mg) at a time twice a day in accelerated or blastic phase.
    For adults with Philadelphia chromosome-positive acute lymphatic leukemia: In general, take 3 tablets (600 mg of imatinib) at a time once a day, after meal. The dosage may be adjusted according to the results of blood tests, age and symptoms.
    In any case, strictly follow the instructions.
  • Take it with a glass of water (about 200 cc) or lukewarm water after meals.
  • If you miss a dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Keep prescribed test schedule. Measure your weight periodically, and consult with your doctor if there is abnormal weight gain.
  • Avoid taking grapefruit juice with this medicine, since it may intensify the therapeutic effects of this medicine.
  • Avoid taking any food containing Saint-John's wort with this medicine since it may diminish medical effects.
  • This medicine may cause dizziness, sleepiness and blurred vision. Take care in working at heights, driving a car or operating dangerous machinery.
  • Sexually active females should use birth control while taking this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include nausea/vomiting, diarrhea, loss of appetite, rash, superficial edema (face, eyelids, lower limbs, etc.), malaise, muscle cramp and fever. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemia, fever, bleeding tendency [marrow depression]
  • headache, disturbance of consciousness, hemiplegia [cerebral hemorrhage, subdural hemorrhage]
  • melena/vomiting of blood, abdominal pain, enlarged feeling of the abdomen, anemia [gastrointestinal bleeding, gastric antral vascular ectasia, gastrointestinal perforation, tumor bleeding]
  • weight increase, chest pain, respiratory distress [serious body fluid retention]
  • fever, dry cough, respiratory distress [interstitial pneumonia, pulmonary fibrosis]
  • facial pallor, respiratory distress, disturbance of consciousness [shock, anaphylaxis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Seek advice of your pharmacy or medical institution about proper disposal of the unused medicines.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

Keywords Search

 

 

 

 

Advanced Search

Browse by drug name A-Z
Browse by drug name A-Z