くすりのしおり

Internal
Published: 6/2014

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ZACRAS Combination Tablets LD
 Active ingredient:
Azilsartan
Amlodipine besilate
 Dosage form:
slightly red tablets, diameter 8.2 mm, thickness 4.7 mm
 Print on wrapping:
(face) ザクラス LD 274, (back) ザクラス LD

Effects of this medicine

This medicine acts antagonistically upon the receptor for angiotensin II which is a pressor substance and also acts on the calcilum channel of smooth muscle of blood vessels to reduce resistance of peripheral blood vessels and eventually lower blood pressure.
It is usually used to treat hypertension.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have renal disorder, liver disorder, cerebrovascular disorder, or hyperkalemia.
    If you are receiving hemodialysis, under low-salt diet treatment, or a preoperative patient.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For adults: In general, take 1 tablet at a time, once a day. Strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible. If there is less than 8 hours to the next dose, skip the missed dose and take the next dose at your regular time. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • As dizziness and light-headedness may appear due to excessive lowering of blood pressure. Therefore, be aware of working at heights or operating dangerous machinery such as driving a car.
    Do not take this medicine together with grapefruits juice as it may enhance antihypertensive effect of the medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include eczema, dizziness, light-headedness, swelling, bradycardia, palpitation, decreased blood presure, hot flash, headache, diarrhea, pain in the pit of stomach, constipation, stomatitis, and gingival hyperplasia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • facial/tongue/throat swelling, breathlessness [angioedema]
  • feeling cold, vomiting, falling unconscious [shock, syncope, loss of consciousness]
  • decreased urination output, swelling of face and hands/feet, fever [acute renal failure]
  • numbness of hands/feet and lips, muscle weakness [hyperkalemia]
  • yellowing of the skin or whites of the eyes, dullness, loss of appetite [liver dysfunction, jaundice]
  • nose bleeding, gingival bleeding, subcutaneous hemorrhage, fever, throat pain [decreased platelet count, decreased white blood cell]
  • bradycardia, dizziness [atrioventricular block]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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