くすりのしおり

Injection
Published: 6/2014

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ZOLEDRONIC ACID INTRAVENOUS INFUSION 4mg/100mL BAG "TOWA" [bone lesion]
 Active ingredient:
Zoledronic acid hydrate
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine relieves bone pain or prevents bone fracture associated with bone metastasis of solid tumors or multiple myeloma.
It is usually used to treat bone lesion associated with bone metastasis of solid tumors and multiple myeloma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have renal disorder.
    If you have recently received dental treatment such as tooth extraction or have a plan to receive it.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, administered by intravenous infusion once every 3 to 4 weeks.
  • It may be administered over a long period according to your response to the treatment.
  • Ask your doctor about your frequency of injection.

Precautions while taking this medicine

  • Maintain your oral hygiene and receive your dental checkup regularly while injecting this medicine.
  • Inform your dentist or oral surgeon that you are receiving this medicine treatment such as tooth extraction or dental implant.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include fever, nausea, dullness, headache, bone pain, joint pain, erythematous eruption (red rash), macular eruption (red rash), angioneurotic edema (swelling of eyelid/lip, breathing difficulty, hives), hives, erythema, bulla, rash, eczema and itch. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • decrease of urine volume, swelling, thirst [acute renal failure, interstitial nephritis]
  • general swelling, breathing difficulty, easy breathing in a sitting position than when lying down [congestive heart failure (swelling, breathing difficulty, pulmonary edema)]
  • fever, dry cough, breathing difficulty [interstitial lung disease]
  • jaw/tooth pain, filling with pus, delay in healing wound after tooth extraction [osteonecrosis of the jaw, osteomyelitis of the jaw]
  • pain of thigh or inguinal region [atypical subtrochanteric and diaphyseal femoral fractures]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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