くすりのしおり

Internal
Revised: 11/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Volibris Tablets 2.5mg
 Active ingredient:
Ambrisentan
 Dosage form:
white tablet, diameter 7.1 mm, thickness 3.7 mm
 Print on wrapping:
(face) ヴォリブリス 2.5 mg, GS K11 (back) Volibris 2.5 mg, ヴォリブリス2.5mg

Effects of this medicine

This medicine antagonizes the endothelin receptor and decreases blood pressure in pulmonary arteries, by suppressing the action of endothelin, a substance that causes contraction of pulmonary arteries, and at the same time, this medicine increases the amount of blood flow in pulmonary arteries to improve shortness of breath and fatigue.
It is usually used to treat pulmonary arterial hypertension.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have liver disorder or pulmonary veno-occlusive disease.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 2 tablets (5 mg of the active ingredient) at a time, once a day. The dosage may be adjusted according to the symptoms. However, the maximum daily dose is 4 tablets (10 mg). If you take this medicine with cyclosporine, the maximum daily dose is 2 tablets (5 mg) at a time, once a day. Strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Use an effective contraceptive method to prevent pregnancy since this medicine may affect the fetus. Consult your doctor if you are pregnant, possibly pregnant or want to become pregnant.
  • Avoid breastfeeding.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include headache, hot flush, nasal congestion and peripheral edema. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • general malaise, dizziness, headache [anemia]
  • edema, breathing difficulty, abdominal bloating [body fluid retention]
  • body dullness, general edema, breathing difficulty [heart failure]
  • cough, respiratory distress, fever [interstitial pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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