くすりのしおり

Internal
Revised: 3/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
DONEPEZIL HYDROCHLORIDE OD TABLETS 5mg "YD"
 Active ingredient:
Donepezil hydrochloride
 Dosage form:
white tablet, diameter : approx. 8 mm, thickness : approx. 2.7 mm
 Print on wrapping:
(front) ドネペジル塩酸塩OD錠5mg「YD」, YD606, 5mg, (back) DONEPEZIL HYDROCHLORIDE OD 5mg, ドネペジル塩酸塩OD錠5mg「YD」, OD5mg, 医師・薬剤師の指示どおり,お飲みください。, お薬は,服用直前まで取り出さないでください。

Effects of this medicine

This medicine inhibits an enzyme in the brain which hydrolyzes the neurotransmitter acetylcholine and slows progression of the symptoms of dementia such as memory loss, repetition of questions or conversations or impaired judgment.
It is usually used to slow progression of symptoms of Alzheimer's disease.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have heart diseases such as sick sinus syndrome, Parkinson's disease/syndrome, a history of gastric/dudenal ulcer, bronchial asthma or obstructive lung disease.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start with taking 3 mg as the active ingredient at a time, once a day for the first one to two weeks, and then take 5 mg once a day. Additionally, if the disease has progressed to the late stage, after taking 5 mg for more than 4 weeks the daily dose is increased up to 10 mg once a day, to be reduced depending on symptom severity. If the dosage is increased to 10 mg once a day, keep watch on the patient's gastrointestinal symptoms due to the adverse reactions of the medicine. This tablet contains 5 mg of the active ingredient. Strictly follow the instructions.
  • When giving the medicine, put it in the mouth and disintegrate it with saliva, and then it is made to swallow as it is, or it gives with a half-full glass of water. However, this medicine should not be given without water while in lying position.
  • If you miss giving a dose, give a dose as soon as you remember. However, if it already has passed half a day from the scheduled time, skip the missed dose and follow the regular dosing schedule. You should never give two doses at one time.
  • If you accidentally give more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop giving this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • In a patient with Alzheimer-type dementia, the ability to operate machinery such as driving a car may decrease. This medicine may cause impaired consciousness, dizziness or drowsiness. Avoid operating dangerous machinery such as driving a car.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, itchiness, loss of appetite, nausea, vomiting, diarrhea, abdominal pain, agitation, restlessness, insomnia and wandering. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • syncope, chest pain, respiratory distress [QT prolongation, ventricular tachycardia, ventricular fibrillation, sick sinus syndrome, sinus arrest, sever bradycardia, cardiac block, syncope]
  • chest pain/pressurized feeling, cold sweat [myocardial infarction, heart failure]
  • heartburn, abdominal pain, black stool/bloody stool, fever [peptic ulcer, duodenal ulcer perforation, gastrointestinal hemorrhage]
  • nausea/vomiting, loss of appetite, yellowing of the skin or whites of the eyes [hepatitis, hepatic dysfunction, jaundice]
  • high fever, muscle stiffness, semi-consciousness [malignant syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • If you have leftover medicines, dispose of them appropriately and do not keep any unused medicine. If you dispose of unused medicines, seek advice of your pharmacist or medical institution how to discard.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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