くすりのしおり

Internal
Published: 9/2013

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
MAINTATE Tablets 2.5mg
 Active ingredient:
Bisoprolol fumarate
 Dosage form:
white scored tablet, diameter: 7.0mm, thickness: 2.7mm
 Print on wrapping:
メインテート2.5mg, メインテート2.5, Maintate 2.5, TA201

Effects of this medicine

This medicine blocks the β1-receptor, which transmits sympathetic nerve excitation to the heart, thus moderating excessive cardiac activity, resulting in antihypertensive, antianginal, antiarrhythmic, and anti-heart failure effects.
It is usually used to treat mild to moderate essential hypertension, angina pectoris, ventricular extrasystole, chronic heart failure (in patients receiving base treatment such as ACE inhibitors, angiotensin II receptor antagonist, diuretic, digitalis preparation) due to ischemic heart disease or dilated cardiomyopathy and tachycardiac atrial fibrillation.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have bradycardia, atrioventricular block, sinoatrial block, sick sinus syndrome, diabetic ketoacidosis, metabolic acidosis, cardiogenic shock, right-sided heart failure caused by pulmonary hypertension, uncompensated heart failure, peripheral circulatory disorder, untreated pheochromocytoma.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For treatment of mild to moderate hypertension, angina pectoris, ventricular extrasystole: In general, for adults, take 2 tablets (5 mg of the active ingredient) at a time, once a day. The dose may be adjusted according to your disease, age and symptom. Strictly follow the instructions.
    For treatment of chronic heart failure:
    <Initiation and dose-adjustment period> In general, for adults, initially take 0.625 mg of the active ingredient at a time, once a day. If you tolerate this medicine for 2 weeks or longer, this means you can continue to take the medicine without any problems, the dose may be increased to 1.25 mg at a time, once a day. Then if you still tolerate this medicine, the dose may be increased stepwise at intervals of at least 4 weeks. However if you no longer tolerate this medicine, the dose may be decreased. Dose increase or decrease is always stepwise, and administration is always once daily. Single dose is usually one of 0.625 mg, 1.25 mg, 2.5 mg, 3.75 mg, or 5 mg. The dosage forms of this medicine include tablets containing 0.625 and 5 mg of the active ingredient, as well as 2.5 mg, and the regimen sometimes involves use of these tablets. In addition, according to your age and symptom, the initial dose may be lower than 0.625 mg/day, and the dose increment may be less than stated above.
    <Maintenance period> In general, take 1.25 to 5 mg at a time, once a day. The dose may be adjusted according to your response to this medicine, and maximum dose should not exceed 5 mg at a time, once a day. Strictly follow the instructions.
    For treatment of tachcardiac atrial fibrillation: In general, for adults, initially take 1 tablets (2.5 mg of the active ingredient) at a time, once a day. If the effect is insufficient, the dose may be up to 2 tablets (5 mg) at a time, once a day. The dose may be adjusted according to your age and symptom, and maximum dose should not exceed 2 tablets (5 mg) at a time, once a day. Strictly follow the instructions.
  • If you miss a dose, take the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause dizziness or light headedness due to antihypertensive action. Be aware of driving a car or operating dangerous machinery. Pay close attention to the beginning of the medication, since the medicine may show the effect strongly.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include bradycardia, dizziness, light headedness, fatigue, heart failure, dyspnea, hypotension, edema, headache, abdominal discomfort and pollakiuria. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • dizziness, breathing difficulty, edema  [heart failure, complete atrioventricular block, severe bradycardia, sick sinus syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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