くすりのしおり

Internal
Revised: 4/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
DENOTAS CHEWABLE CONBINATION TABLETS
 Active ingredient:
Precipitated calcium carbonate
Cholecalciferol
Magnesium carbonate
 Dosage form:
Almost white to pale yellow tablet, diameter: 14.1 mm, thickness: 6.4 mm
 Print on wrapping:
デノタスチュアブル配合錠, (plastic bottle) 56錠 or 100錠, (SP) DENOTAS

Effects of this medicine

This medicine contains calcium, natural vitamin D3 (cholecalciferol) and magnesium carbonate. Blood calcium is engaged in actions such as neurotransmission, muscle contraction and blood coagulation. Natural Vitamin D (Vitamin D2 and D3) is metabolized in the liver to 25(OH) D and then turns into activated vitamin D [1, 25(OH)2D] in the kidney. It increases the blood calcium by promoting calcium absorption in the small intestine and enhancing calcium reabsorption in the renal tubular. Magnesium is involved in calcium metabolism.
It is usually used to treat or prevent hypocalcemia associated with the use of RANKL inhibitors (denosumab [recombinant], etc.).

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have hypercalcemia or renal disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 2 tablets at a time, once daily. However, the dosage should be adjusted based on age and symptoms of the patient. Strictly follow the instructions.
  • This medicine is chewable. Chew or dissolve the tablet in your mouth.
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one dose. Never double the prescribed dose at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Blood calcium may have to be measured while medication. Please follow your doctor's instructions and take a test on your designated date and time.
  • Be aware that disorders such as hypercalcemia may occur when you drink a large amount of milk during medication.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, erythema, itch, constipation and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out the reach of children. Store away from light, heat and moisture.
  • In case of plastic bottle, screw the cap tightly after use.
  • Do not replace the contents to a different container.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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