くすりのしおり

Injection
Revised: 12/2013

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
ISOVORIN INJECTION 100mg
 Active ingredient:
Levofolinate calcium
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine boosts the effectiveness of antitumor effect with concomitant use of fluorouracil.
Usually, used for the purpose of enhancing the effect of fluorouracil for the treatment of gastric cancer (which is inoperable or recurrent), colorectal cancer and pancreatic cancer not amenable to curative resection.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash etc.) to any medicines.
    If you have: fever, generalized dullness, diarrhea, varicella (chickenpox) or other infectious disease, ascites, pleural effusion, heart disease or its history, poor general condition, discontinuation of receiving the combination preparation of tegafur, gimeracil and oteracil potassium (TS-1) within 7 days, liver disease, renal disease, liver metastasis, gastrointestinal ulcer or hemorrhage, ongoing treatment by radiation.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, this medicine is administered by intravenous drip infusion at one time over the period of 2 hours.
  • The administration intervals depend on concomitant drugs and symptoms/condition. Contact your doctor about the specific dosing schedule.

Precautions while taking this medicine

  • If you have decreased bone-marrow function, infection or bleeding may tend to occur. However, it is difficult to find out these symptoms so that you should receive clinical examination (blood test, liver/renal function test, etc) regularly (frequently during early treatment period, in particular) to find any symptoms early.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, loss of appetite, nausea/vomiting, stomatitis, fever, rash, taste abnormality, abdominal pain, epigastric pain, thirst, constipation, gum inflammation, cheilitis, melena, angular cheilitis, tongue inflammation, heartburn and abdominal bloating. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • persistent muddy or watery stool [severe diarrhea]
  • chill, fever, bleeding tendency [bone-marrow depression]
  • severe abdominal pain, diarrhea [serious enteritis]
  • breathing difficulty, generalized hot flashes, urticaria [shock, anaphylaxis]
  • dullness, loss of appetite, yellowing of the skin or whites of the eyes [liver dysfunction, jaundice]
  • decreased urine output, swelling of limbs, dullness [acute renal failure]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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