くすりのしおり

Self-injection
Revised: 10/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Humalog Mix25 Cart
 Active ingredient:
Insulin lispro(genetical recombination)
 Dosage form:
cloudy or milky injectable preparation
 Print on wrapping:

Effects of this medicine

This medicine decreases your blood glucose level through effects including intracellular glucose uptake, inhibition of gluconeogenesis in the liver, and promotion of glycogen synthesis in liver and/or muscle tissue.
It is usually used for treatment of diabetes which is candidate for insulin therapy.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you have symptoms of hypoglycemia.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, subcutaneously inject 4 to 20 units of the active ingredient at a time, twice a day immediately before breakfast and dinner. In case you use this medicine with once-daily regimen, it should be subcutaneously injected immediately before breakfast. Although the dosage should be adjusted according to the symptoms and laboratory examination, the maintenance dose is generally 4 to 80 units per day. Strictly follow the instructions.
  • Evenly shake the medicine to be homogeneously suspended before each injection, then inject it strictly before (within 15 minutes) each meal.
  • Inject this medicine subcutaneously into your abdomen, thighs, upper arms or buttocks. Choose your injection part, and change the injection site for every dosing within the chosen injection part, because the rate of insulin absorption is affected by the injection part. Injection site should be at least 2 to 3 cm apart from the previously injected point.
  • Inject the medicine with a pen-shaped insulin injector designed for this preparation. Do not share an injector and/or a cartridge with other people.
  • If you miss a dose, consult with your doctor. You should never inject two doses at one time.
  • If you accidentally inject more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop injecting this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause severe hypoglycemia. Take extra care of prevention and treatment of hypoglycemia. If hypoglycemia occurred when you are engaged in dangerous operations such as working at heights or driving a car, it may cause an accident. Be aware of this point when you are engaged in these operations. Be sure to tell this precaution to your family members and friends.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hypoglycemia and injection site reaction (swelling, itching, pain, redness). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • severe sense of hunger, weakness, tremor (shaking of limbs) [hypoglycemia]
  • respiratory distress, sweat, whole body rash [anaphylactic shock]
  • swelling in eyelid/lips, breathing difficulty [angioneurotic edema]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. For unused medicine, keep in refrigerator (2 to 8degrees Celsius), avoid freezing. For in-used medicine, DO NOT keep in refrigerator. Store the pen-shaped insulin injector with cartridge attached away from direct sunlight, heat and humidity. Use up within 28 days after beginning of use.
  • Discard the remainder. Do not store them. Ask your pharmacist or your health-care provider how to discard.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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