くすりのしおり

Internal
Revised: 9/2017

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Mirapex-LA Tablets 1.5mg
 Active ingredient:
Pramipexole hydrochloride hydrate
 Dosage form:
white tablet, major axis: approx. 14 mm, minor axis: approx. 6.8 mm, thickness: approx. 4.8 mm, weight: approx. 0.35 g
 Print on wrapping:
(Face) Mirapex LA錠 1.5mg, 1日1回服用, P3, (Back) ミラペックスLA錠 1.5mg, 1日1回服用, 湿気に注意, company logo, Boehringer Ingelheim

Effects of this medicine

This medicine stimulates dopamine D2 receptors in the brain to improve symptoms of Parkinson's disease (shaking of hands, muscle stiffness, slow movement and inability to maintain posture).
It is usually used to treat Parkinson's disease.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have renal disorder requiring dialysis.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, start with 0.375 mg of the active ingredient after the meal once daily for the first week, and increase to 0.75 mg daily for the second week. Thereafter increase the daily dose by an increment of 0.75 mg at weekly intervals by checking your condition and your maintenance dose is determined (standard daily dose: 1.5 to 4.5 mg). The dosage may be adjusted according to the age or symptoms, but the maximum daily dose should not exceed 4.5 mg. This preparation contains 1.5 mg of the active ingredient in a tablet. Strictly follow the instructions.
  • Swallow the tablet without chewing. Adverse reactions may occur when you break or crunch the tablets.
  • If you miss a dose, take the missed dose as soon as possible. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so. Adverse reactions may occur especially if you rapidly decrease the amount of dosage or stop your medication.

Precautions while taking this medicine

  • Car accidents have been reported caused by somnolence or sudden onset of sleep without warning signs. Do not engage in hazardous activities such as driving a car, operating machinery or working at heights.
  • Avoid drinking alcohol since it may increase the effects of this medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include somnolence (state close to sleep with impaired consciousness), nausea, peripheral edema, dizziness, fatigue, constipation, visual hallucination, dyskinesia (involuntary movements of mouth and tongue and uncontrollable movements of hands), postural hypotension and hallucination. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • sudden onset of sleep without warning signs  [sudden onset of sleep]
  • seeing or hearing things that are not really there, groundless subjective belief, impaired mind [hallucination, delusion, delirium, confusion, agitation]
  • convulsion, consciousness disorder [syndrome of inappropriate secretion of antidiuretic hormone (SIADH)]
  • fever, strong muscle stiffness, decreased consciousness [neuroleptic malignant syndrome]
  • lassitude, muscle pain, brown urine [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Seek advice of your pharmacy or medical institution about proper disposal of the unused medicines.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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