くすりのしおり

Internal
Published: 9/2009

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
MABLIN POWDER 1%
 Active ingredient:
Busulfan
 Dosage form:
white to yellowish white powder
 Print on wrapping:

Effects of this medicine

This medicine inhibits DNA synthesis which is essential for multiplication of cells and consequently suppresses overgrowth of abnormal cells.
It is usually used to improve subjective/objective symptoms of chronic myelogenous leukemia or polycythemia vera.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
    If you are a patient with hepatic/renal disorder, myelosuppression, coexisting infection, lung disorder or chicken pox.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • General dosage regimen:
    For treatment of chronic myelogenous leukemia
    , (method 1) for adults, take 0.4-0.6 g (4-6 mg of the active ingredient) a day. After monitoring your level of white blood cells decreases to near the baseline (15,000/mm3) the dose is decreased to 0.2 g (2 mg) or less a day. (method 2) For adults, take 0.2 g (2 mg of the active ingredient) or less a day till your level of white blood cells decreases to near the baseline (15,000/mm3). (both method 1,2) As maintenance therapy, take 0.2 g (2mg) at a time, once in a week or two weeks.
    For treatment of polycythemia vera
    , for adults, 0.2-0.4 g (2-4 mg of the active ingredient) a day. The dose is increased gradually up to 0.6 g (6 mg) a day according to the result of blood tests. After the symptoms are improved, the dose should be decreased and maintained.
    In any case, the dosage should be adjusted to the disease to be treated, age or symptoms. Strictly follow the instructions of your doctor/pharmacist.
  • Take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
  • If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
  • Do not stop taking the medicine without the instructions of your doctor.

Precautions while taking this medicine

  • While taking the medicine you have laboratory tests (blood test, liver/renal function test) frequently. Do not miss your appointments and have tests orderly.

Possible adverse reactions to this medicine

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: rash, urticaria, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • anemia, fever, bleeding tendency  [myelosuppression]
  • fever, cough, breathing difficulty  [interstitial pneumonia, pulmonary fibrosis]
  • sensitive to bright light, foggy vision, failing eyesight  [cataract]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacy how to discard.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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