くすりのしおり

Internal
Revised: 2/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
RIFADIN Capsules 150mg
 Active ingredient:
Rifampicin
 Dosage form:
capsule with blue opaque cap and red opaque body (entire length: 15.8 mm)
 Print on wrapping:
リファジン150mg, Rifadin150mg

Effects of this medicine

This medicine is a chemotherapeutic agent and shows antibacterial effect by inhibiting RNA synthesis of Mycobacterium tuberculosis.
It is usually used to treat pulmonary tuberculosis, other tuberculosis, nontuberculous mycobacteriosis including Mycobacterium avium complex(MAC), and Hansen's disease.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash etc.) to any medicines.
    If you had once stopped taking the medicine.
    If you are a patient with biliary atresia, liver disorder, adrenal disorder, or thyroid disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For pulmonary tuberculosis and other tuberculosis: In general, for adults, take 3 capsules (450 mg of the active ingredient) at a time, once daily, everyday. However, if you need to take other antituberculosis medicines concomitantly, you may be instructed to take the medicine 2 days a week. Take the medicine before breakfast in principle. The dosage may be adjusted according to the age or symptoms. Strictly follow the instructions of your doctor/pharmacist.
    For nontuberculous mycobacteriosis including MAC: In general, for adults, take 3 capsules (450 mg of the active ingredient) at a time, once daily, everyday. Take the medicine before breakfast in principle. The dosage may be adjusted according to the age, symptoms or weight, however, the maximum daily dose is 4 capsules (600 mg). Strictly follow the instructions of your doctor/pharmacist.
    For Hansen's disease
    : In general, for adults, take 4 capsules (600 mg of the active ingredient) at a time once to twice a month, or take 3 capsules (450 mg of the active ingredient) at a time, once daily, every day. Take the medicine before breakfast in principle. The dosage may be adjusted according to the age or symptoms. Strictly follow the instructions of your doctor/pharmacist.
  • If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking the medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include gastrointestinal disorder, rash, fever, liver disorder and headache. If any of these symptoms occur,consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • loss of appetite, general malaise, yellowing of the skin/white of eyes  [serious liver disorder including fulminant hepatitis]
  • chill, facial flushing, breathing difficulty  [shock, anaphylaxis]
  • fever, general malaise, urine output decreased, swelling of limbs and face  [renal failure, interstitial nephritis, nephrotic syndrome]
  • general malaise, palpitation, dizziness  [hemolytic anemia]
  • fever, sore throat, muscle pain, bleeding tendency (nasal bleeding, gums bleeding, subcutaneous hemorrhage, etc.)  [agranulocytosis, thrombocytopenia]
  • abdominal pain, frequent diarrhea, nausea  [serious colitis associated with melaena such as pseudomembranous colitis]
  • fever, erythema, blister, erosion  [toxic epidermal necrolysis, oculomucocutaneous syndrome, lichenoid eruption, pemphoid eruption, pemphigoid eruption, erythroderma (exfoliative dermatitis)]
  • fever, dry cough, breathing difficulty  [interstitial pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight and heat.
  • Avoid storing the medicine in a humid place since the medicine is hygroscopic.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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