くすりのしおり

Internal
Published: 12/2008

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
LEUKERIN POWDER 10%
 Active ingredient:
Mercaptopurine
 Dosage form:
yellowish white powder
 Print on wrapping:

Effects of this medicine

This medicine suppresses excessive growth of abnormal cells by inhibiting synthesis of adenine and guanine nucleotide which are components of DNA required for the growth of cells.
It is usually used for the remission of subjective and objective symptoms in acute leukemia and chronic myeloid leukemia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you ever experienced any allergic reaction (itch, rash, etc.) to any medicine.
    If you are a patient with hepatic or renal disorder, myelosuppression, complicating infection, or varicella (chickenpox).
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • General dosage regimen: For adults, take 0.02 to 0.03 g/kg (2 to 3 mg of the active ingredient) daily, individually or concurrently with other medicine. After the remission, take smaller amounts of remission-inducing dose, individually or concurrently with other medicine. The dosage may be adjusted according to the age or symptoms. Strictly follow the instructions of your doctor/pharmacist.
  • Laboratory tests (blood tests, hepatic and renal function tests) will be frequently performed during receiving the treatment with the medicine, therefore, make sure to visit the hospital and undergo the tests on predetermined days. If any abnormality is found, the dosage will be decreased or the medication will be discontinued.
  • Take a dose as soon as possible when you remembered that you missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
  • If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
  • Do not stop taking the medicine without the instructions of your doctor.

Precautions while taking this medicine

Possible adverse reactions to this medicine

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: jaundice, rash, erythema, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • amemia, fever, bleeding tendency  [myelosuppression]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep the medicine out of the reach of children. Store it away from direct sunlight, heat and moisture.
  • Do not store the remainder and ask your pharmacist how to discard it.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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