くすりのしおり

Internal
Revised: 3/2010

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
UBRETID TAB. 5mg
 Active ingredient:
Distigmine bromide
 Dosage form:
white tablet (φ: 9.0 mm, thickness: 3.0 mm)
 Print on wrapping:
ウブレチド錠5mg, UBRETID TAB.5mg, TO-067

Effects of this medicine

This medicine reversibly inhibits cholinesterase to enhance action of acetylcholine indirectly. It consequently strengthens the function of muscles/bladder muscle.
It is usually used to treat myasthenia gravis, dysuria due to hypotonic bladder such as neurogenic bladder or after surgery.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
    If you are a patient with organic obstruction of the digestive tract or urinary tract, vagotonia.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • General dosage regimen:
    For dysuria due to hypotonic bladder such as neurogenic bladder or after surgery
    , for adults, take 1 tablet (5 mg of the active ingredient) daily.
    For myasthenia gravis
    , for adults, take 1-4 tablet(s) (5-20 mg of the active ingredient) daily in 1-4 divided dose(s). Start with 1 tablet (5 mg) daily, and the dose should be adjusted according to symptoms. Strictly follow the instructions of your doctor/pharmacist.
  • When you realize that you missed, skip the missed dose, and take a single dose at the next regularly scheduled time. DO NOT take double doses to make up for the missed dose.
  • If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
  • Do not stop taking the medicine without the instructions of your doctor.

Precautions while taking this medicine

  • Be sure to inform your family and people around you, that you must stop taking the medicine and report your doctor immediately if you have the symptoms of side effects below.

Possible adverse reactions to this medicine

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: nausea/vomiting, abdominal pain, diarrhea, increased salivation, hypersecretion in respiratory tract, sweating, bradycardia, miosis, difficulty in breathing, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • nausea/vomiting, abdominal pain, diarrhea  [cholinergic crisis]
  • chest pain, chest discomfort/oppression, dizziness  [angina, arrhythmia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist how to discard.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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