くすりのしおり

Internal
Revised: 9/2009

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
MADOPAR Combination Tablet
 Active ingredient:
Levodopa
Benserazide hydrochloride
 Dosage form:
pale red tablet (φ: approx. 9mm, thickness: approx. 3.3mm)
 Print on wrapping:
マドパー配合錠

Effects of this medicine

The active ingredient of this medicine, Levodopa, changes into dopamine in the brain and improves symptoms of Parkinson disease and etc. It is usually used to treat Parkinson disease and parkinsonian syndrome.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
    If you are a patient with glaucoma, hepatic/renal disorder, diabetes, heart/lung disease, bronchial asthma, endocrine system disease, neurological manifestation such as suicide tendency, or osteomalacia.
    If you have/had gastric/duodenal ulcer.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • General dosage regimen: If you have not taken Levodopa so far: For adults, take 1-3 tablet(s) in 1-3 divided doses a day, after meal on the first day. Gradually increase the dosage by 1-2 tablet(s) a day every 2-3 days. The maintenance dosage is 3-6 tablets a day. It should be adjusted according to your disease, age and symptoms. Strictly follow the instructions of your doctor/pharmacist.
    If you are taking Levodopa now
    : For adults, take Levodopa equivalent to about 1/5 of the daily amount which you are taking (1 tablet contains 100mg of Levodopa) on the first day. Take it in 1-3 divided doses a day, after meal. Gradually increase or decrease the amount of this medicine after that. The maintenance dosage is 3-6 tablets a day. It should be adjusted according to your disease, age and symptoms. Strictly follow the instructions of your doctor/pharmacist.
  • Take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose.
  • If you took too much of this medicine (more than ordered), check with your doctor/pharmacist.
  • Do not stop taking this medicine without the instructions of your doctor.

Precautions while taking this medicine

  • This medicine may cause sudden and temporary sleepiness, diminished attention, or decreased reflection ability. Do not drive a car, work at heights, or operate dangerous machinery.

Possible adverse reactions to this medicine

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: involuntary movement, nausea/vomiting, loss of appetite, hallucination, sleeplessness, rash, urticaria-like eczema.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • breathlessness with fever, stiff muscles in the limbs, absent-mindedness, loss of consciousness [syndrome malin]
  • hallucination, depression and indisposition, loss of appetite, lassitude, sleeplessness, impaired judgment, inability to have normal thoughts [hallucination, depression, confusion]
  • bad abdominal pain, vomiting, vomiting of blood [worsening of gastric/duodenal ulcer]
  • easy fatigability, anemia [hemolytic anemia]
  • sudden and temporary sleepiness [sudden onset of sleep]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store at room temperature (1-30℃), away from light and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist how to discard.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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