くすりのしおり

Internal
Revised: 4/2019

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
VALERIN Syrup 5%
 Active ingredient:
Sodium valproate
 Dosage form:
colorless to faintly yellowish clear solution
 Print on wrapping:

Effects of this medicine

This medicine works on central nerve system and increases GABA concentration in the brain in order to control epilepsy seizure. It also improves unstable mood caused by epilepsy as well as suppresses uncontrollable excitation and behavior, and migraine attack.
It is usually used to treat epilepsy of every kinds, character and behavior disorder (bad mood, irritability, etc.) accompanied by epilepsy, mania, and manic-state in bipolar disorder. It also used to suppress migraine attack, however, it should not be used to treat migraine attack which has already developed.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are a patient with hepatopathy or urea cycle disorders.
  • If you are pregnant, breastfeeding or possibity pregnant.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For epilepsy, mania, and manic-state in bipolar disorder: In general, for adults, take 8 to 24 mL (400 to 1,200 mg of the active ingredient) in 2 to 3 divided doses a day. The dose may be adjusted according to your age and symptoms.
    For suppression of migraine attack: In general, for adults, take 8 to 16 mL (400 to 800 mg of the active ingredient) in 2 to 3 divided doses a day. The dose may be adjusted according to your age and symptoms. The daily dosage is restricted to 20 mL(1,000 mg). Strictly follow the instructions in any case.
  • If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never give two doses at one time.
  • If you accidentally took more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • This medicine may cause sleepiness, diminished attention, loss of concentration, decreased reflex motor capacity, etc. Therefore do not drive a car or operate dangerous machinery while taking it.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include somnolence, nausea, vomiting and rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • generalized fatigability, loss of appetite, nausea [serious hepatopathy]
  • flapping tremor, faint consciousness, impaired mind [consciousness disorder accompanied by hyperammonemia]
  • anemic condition, generalized fatigability, top-heavy feeling [hemolytic anemia, pure red cell aplasia, pancytopenia, thrombocytopenia, granulocytopenia]
  • bad upper abdominal pain, lumbar backache, fever [acute pancreatitis]
  • fever, rash, joint pain [interstitial nephritis, Fanconi's syndrome]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from heat, moisture and direct sunlight.
  • Discard the remainder. Do not store them.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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